Biomechanical forces promote embryonic haematopoiesis

Biomechanical forces promote blood development through prostaglandin E2 and the cAMP–PKA signaling axis

Blood flow promotes emergence of definitive hematopoietic stem cells (HSCs) in the developing embryo, yet the signals generated by hemodynamic forces that influence hematopoietic potential remain poorly defined. Here we show that fluid shear stress endows long-term multilineage engraftment potential upon early hematopoietic tissues at embryonic day 9.5, an embryonic stage not previously describ...

Zebrafish Caudal Haematopoietic Embryonic Stromal Tissue (CHEST) Cells Support Haematopoiesis

Haematopoiesis is an essential process in early vertebrate development that occurs in different distinct spatial locations in the embryo that shift over time. These different sites have distinct functions: in some anatomical locations specific hematopoietic stem and progenitor cells (HSPCs) are generated de novo. In others, HSPCs expand. HSPCs differentiate and renew in other locations, ensurin...

Embryonic Stem Cell Differentiation – A Model System to Study Embryonic Haematopoiesis

Biomechanical Analysis of Forces and Moments Generated in the Mandible

The forces generated during the function of the stomatognatic system act to the jaw bones in different directions depending on action of muscles which do definite action. The objective of this study is to determine distribution of the forces and their moments in some parts of a toothless mandible during simulation of one-sided ridge loading in the region of the lateral teeth. The chosen researc...

Impaired embryonic haematopoiesis yet normal arterial development in the absence of the Notch ligand Jagged1.

Specific deletion of Notch1 and RBPjkappa in the mouse results in abrogation of definitive haematopoiesis concomitant with the loss of arterial identity at embryonic stage. As prior arterial determination is likely to be required for the generation of embryonic haematopoiesis, it is difficult to establish the specific haematopoietic role of Notch in these mutants. By analysing different Notch-l...